anethole, a medicinal plant compound, decreases the production of pro-inflammatory tnf-α and il-1β in a rat model of lps-induced periodontitis

نویسندگان

janet moradi department of periodontics, dental school, hamadan university of medical sciences

fatemeh abbasipour department of periodontics, dental school, hamadan university of medical sciences

jalal zaringhalam dep. of physiology, medical school, shahid beheshti university of medical sciences

narges ziaee department of periodontics, dental school, hamadan university of medical sciences, hamadan, iran

چکیده

periodontitis (pd) is known to be one of most prevalent worldwide chronic inflammatory diseases. there are several treatments including antibiotics for pd; however, since drug resistance is an increasing problem, new drugs particularly derived from plants with fewer side effects are required. the effects of trans-anethole on il-1 β and tnf-α level in a rat model of pd were investigated and compared to ketoprofen.eschericia coli lipopolysaccharide (lps, 30 µg) was injected bilaterally into the palatal gingiva (3µl/site) between the upper first and second molars every two days for 10 days in anesthetized rats. administration of either trans-anethole (10 or 50mg/kg, i.p.) or ketoprofen (10 mg/kg, i.p.) was started 20 minute before lps injection and continued for 10 days. then, il-1β and tnf-α levels were measured in blood samples by elisa at day 0 (control) and at day 10. anethole at both concentrations significantly suppressed il-1β and tnf-α production when compared to lps-treated rats. the suppressive effects of anethole on lps-induced pro-inflammatory cytokines were almost similar as seen with ketoprofen.in conclusion, the present results suggest that anethole may have a potent inhibitory effect on pd through suppression of pro-inflammatory molecules; therefore it could be a novel therapeutic strategy for pd.

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Anethole, a Medicinal Plant Compound, Decreases the Production of Pro-Inflammatory TNF-α and IL-1β in a Rat Model of LPS-Induced Periodontitis

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عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۳، شماره ۴، صفحات ۱۳۱۹-۱۳۲۵

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